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Festival Genomics

Research and Development

Covering

What will our gene edited future look like? Does our definition of scientist need updating & how can we transform techniques in single cell analysis, CRISPR and difficult samples to fully unlock the transformative power of genomics.
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09:25 AM
    • Enabling Data
    • Personalizing Medicine
    • Precision Therapies
    • Research and Development
    Who is a Scientist? How biohackers are changing the world
    Main Stage
    The rise & limitations of the independent scientist Influence of biohacking on genetic engineering Why we should support biohackers by being more accessible as a community
09:50 AM
    • Enabling Data
    • Personalizing Medicine
    • Precision Therapies
    • Research and Development
    Transformative legacy of genomics - thinking out of the box
    Main Stage
    Genomics is well known for its transformative effects on biomedical research but its contributions are much broader and more fundamental Thanks to its insistence on open data sharing genomics has laid ...
10:50 AM
11:00 AM
    • Research and Development
    How to genetically engineer a human in your garage
    Knowledge Hub B
12:35 PM
    • Research and Development
    Our gene-edited future: dreams vs reality
    Main Stage
    Editing: targets that could bring clinical benefit Progress in the clinic so far What stands between hopes and reality  
01:00 PM
    • Precision Therapies
    • Research and Development
    Advanced CRISPR/Cas9 Genome Editing Technology in Mammalian Systems
    Main Stage
    CRISPR/Cas9 System •    Background & mechanism •    Off-target reduction Applications •    Gene knockout & insertion •    Transgenic animal models New CRISPR Formats •    Epigenetic activators •    Sy ...
02:40 PM
    • Research and Development
    Therapeutic targeting of toxic RNA using CRISPR/Cas9
    Knowledge Hub B
    CRISPR/Cas9 can be programmed to target microsatellite RNA Different protein tags on Cas9 can lead to tracking and degradation of target RNAs CRISPR/Cas9 can used as a therapeutic tool for RNA mediate ...
03:00 PM
    • Research and Development
    Beyond DNA: Expanding the power of CRISPR to RNA
    Knowledge Hub B
    CRISPR is a powerful way to edit human DNA CRISPR may someday support cures for genetic diseases but many diseases are linked to another important molecule: RNA
03:20 PM
    • Research and Development
    Streamlining tools for robust, stable CRISPR mediated transcriptional activation
    Knowledge Hub B
    • CRISPR mediated transcriptional activation (CRISPRa) is a powerful tool for studying gene activation from endogenous loci and for gain of function genomic screens • Many such studies require the use ...
04:20 PM
    • Research and Development
    Therapeutic strategies via CRISPR-Cas: new approaches and new challenges
    Main Stage
    The recent advent of RNA-guided effectors derived from clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems have dramatically transformed our ability to e ...
09:45 AM
    • Enabling Data
    • Personalizing Medicine
    • Precision Therapies
    • Research and Development
    Patients at the center of precision medicine
    Main Stage
    What are the best strategies to stay nimble yet provide scale in today’s environment to provide two way communication between patients and a data gathering center? Building a team for Data, Technology ...
10:55 AM
    • Research and Development
    Overcoming difficulties in accessing metastatic tissue
    Knowledge Hub B
    Creating a clinical contact Determining IRB necessity Logging tissue Closing the loop    
12:45 PM
    • Research and Development
    Exploring the utility of CTCs earlier in the disease process: the true needle in a haystack
    Main Stage
    Use of a CTC platform with no pre-enrichment Whether CTCs exist post radical prostatectomy How to genomically assess CTCs for copy number A glimpse at the clinical utility of CTCs in this context
01:10 PM
    • Research and Development
    Mitigating the challenges of nucleic acid extraction from FFPE samples
    Main Stage
    Understanding the unique challenges in performing genomic assays from FFPE derived nucleic acids. The importance of isolating both DNA and RNA from a single FFPE sample.   New technologies and approac ...
02:20 PM
    • Research and Development
    Single-nucleus RNA-seq reveals unique transcriptional response in the dentate gyrus in response to hippocampal activation
    Knowledge Hub B
    Single-nucleus RNA-seq is the optimal method to examine activity-induced expression single-neuron expression of activity-induced genes cell-specific activity-induced expression
02:45 PM
    • Research and Development
    Single cell resolution of highly diverse subpopulations in the mammalian kidney achieved with high throughput single cell RNA-sequencing
    Knowledge Hub B
    Use of single cell RNAseq on the BD Resolve platform Use of single cell RNAseq to open doors in kidney research Utility of RNAseq to uncover mechanisms of disease in heterogeneous cell mixtures
03:35 PM
    • Research and Development
    Single cell and nucleus genomics: opportunities, challenges, and recent progress on RNA-seq and whole genome sequencing
    Main Stage
    RNA-seq from single nuclei and the challenges of using dissociated whole cells. Single neuron analysis of memory formation in the hippocampus. High throughput RNA-seq and advances in quality control o ...

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